Scans from my Nikon LS-30 are quite noisy. Vuescan features “grain reduction” but I have found that for using Neatimage instead provides better results. I have had satisfying results with the Nikon Coolscan V profiles by Tom Lane using Neatimage‘s “remove more chrominance noise” preset.

At the moment there are no other Nikon slide scanner profiles. Since Neatimage profiles depend on the film and on the exposure, I guess I will have to produce a better matching profile myself.